Quality measurement, control, and improvement in combinatorial
chemistry
Combinatorial chemistry has developed rapidly in the past decade,
with great advances made by scientists working on analysis and
purification of a large number of compounds and the analysis of
polymer-bound compounds. However, formidable challenges lie ahead
of today's researcher. For example, high-throughput analysis and
purification technologies must be further developed to ensure
combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial
Chemistry describes various analytical techniques and systems for
the development, validation, quality control, purification, and
physicochemical testing of combinatorial libraries. A new volume in
Wiley's Chemical Analysis series, this text has four parts
covering:
* Various approaches to monitoring reactions on solid support and
optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of
libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and
post-purification stages
Drawing from the contributions of respected experts in
combinatorial chemistry, this comprehensive book provides coverage
of applications of Nuclear Magnetic Resonance (NMR), liquid
chromatography/mass spectrometry (LC/MS), Fourier Transform
Infrared (FTIR), micellar electrokinetic chromatography (MEKC)
technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to the
library of students and researchers studying or working in
analytical chemistry, combinatorial chemistry, medicinal chemistry,
organic chemistry, biotechnology, biochemistry, or biophysics.
